Article
Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2020
Perumal Deepak, Imai Naoko, Laganà Alessandro, Finnigan John, Melnekoff David, Leshchenko Violetta V, Solovyov Alexander, Madduri Deepu, Chari Ajai, Cho Hearn Jay, Dudley Joel T, Brody Joshua D, Jagannath Sundar, Greenbaum Benjamin, Gnjatic Sacha, Bhardwaj Nina, Parekh Samir
Abstract excerpt
PURPOSE: Somatic mutations in cancer cells can give rise to novel protein sequences that can be presented by antigen-presenting cells as neoantigens to the host immune system. Tumor neoantigens represent excellent targets for immunotherapy, due to their specific expression in cancer tissue. Despite the widespread use of immunomodulatory drugs and immunotherapies that recharge T and NK cells, there has been no...
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