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Article

Intron-Retention Neoantigen Load Predicts Favorable Prognosis in Pancreatic Cancer.

JCO clinical cancer informatics - 1 Feb 2022

Dong Chuanpeng, Reiter Jill L, Dong Edward, Wang Yue, Lee Kelvin P, Lu Xiongbin, Liu Yunlong

Abstract excerpt

PURPOSE: High tumor mutation burden (TMB) in many cancer types is associated with the production of tumor-specific neoantigens, a favorable outcome and response to immune checkpoint blockade (ICB) therapy. Besides mutation-derived neoantigens, aberrant intron retention also produces tumor neopeptides that could trigger an immune response. The relationship between intron-retention-derived tumor neoantigens...

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Identifiers

PMID: 35148169
DOI: 10.1200/CCI.21.00124
PMCID: PMC8846286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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