Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer.

International journal of molecular sciences - 2 Sept 2021

Melo Camila Morais, Vidotto Thiago, Chaves Luiz Paulo, Lautert-Dutra William, Reis Rodolfo Borges Dos, Squire Jeremy Andrew

Abstract excerpt

Immunotherapy has improved patient survival in many types of cancer, but for prostate cancer, initial results with immunotherapy have been disappointing. Prostate cancer is considered an immunologically excluded or cold tumor, unable to generate an effective T-cell response against cancer cells. However, a small but significant percentage of patients do respond to immunotherapy, suggesting that some specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic
Share to Genes, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy

Share to Neoplasms, Experimental

Share to Prostatic Neoplasms

Share to Single-Cell Analysis

Share to Spatial Analysis

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34502458
DOI: 10.3390/ijms22179550
PMCID: PMC8431051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer.PMID 34502458Read ↗

Germline and somatic mutations in prostate cancer: Implications for treatment.Semantic proximity Read ↗

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.Semantic proximity Read ↗

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.Semantic proximity Read ↗

Immunome profiling in prostate cancer: a guide for cliniciansSemantic proximity Read ↗

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancerSemantic proximity Read ↗

Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine.Semantic proximity Read ↗

Genetic alterations in human prostate cancer: a review of current literature.Semantic proximity Read ↗

Prognostic and therapeutic implications of DNA repair gene mutations in advanced prostate cancer.Semantic proximity Read ↗

FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer.Semantic proximity Read ↗

Clinical Implications of Mismatch Repair Deficiency in Prostate CancerSemantic proximity Read ↗

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistanceSemantic proximity Read ↗

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.