Article
Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine.
Molecular diagnosis & therapy - 1 Apr 2017
Alvarez-Cubero M J, Martinez-Gonzalez L J, Robles-Fernandez I, Martinez-Herrera J, Garcia-Rodriguez G, Pascual-Geler M, Cozar J M, Lorente J A
Abstract excerpt
The molecular cause of prostate cancer (PCa) is still unclear; however, its progression involves androgen, PI3K/Akt, and PTEN signaling, as cycle and apoptotic pathways. Alterations in oncogenes and tumor suppressor genes as PIK3CA, BRAF, KRAS and TP53 are not very common. Recently, somatic mutations have been discovered in relation to cancer progression mainly in genes such as PIK3CA; however, little data has...
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