Article
FLG Gene Mutation Up-regulates the Abnormal Tumor Immune Response and Promotes the Progression of Prostate Cancer.
Current pharmaceutical biotechnology - 1 Jan 2022
Zhang Peng, An Zesheng, Sun Changhai, Xu Yong, Zhang Zhihong
Abstract excerpt
BACKGROUND: Prostate Cancer (PCa) ranks sixth with regard to the cause of cancerinduced male diseases worldwide, and inflammation is closely associated with its morbidity, deterioration, and prognosis. Tumor Mutation Burden (TMB) is identified to be the most common biomarker for the prediction of immunotherapy. But it is still unclear about the relationship of gene mutations in PCa with TMB and immune response....
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