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Article

Tumor microenvironment heterogeneity an important mediator of prostate cancer progression and therapeutic resistance

4 May 2022

Abstract excerpt

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summarize the challenges targeting the tumor environments, and emphasize...

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PMID: 35508696
DOI: 10.1038/s41698-022-00272-w

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