Article
Tumor Immunity and Survival as a Function of Alternative Neopeptides in Human Cancer.
Cancer immunology research - 1 Mar 2018
Rech Andrew J, Balli David, Mantero Alejandro, Ishwaran Hemant, Nathanson Katherine L, Stanger Ben Z, Vonderheide Robert H
Abstract excerpt
The immune system exerts antitumor activity via T cell-dependent recognition of tumor-specific antigens. Although the number of tumor neopeptides-peptides derived from somatic mutations-often correlates with immune activity and survival, most classically defined high-affinity neopeptides (CDNs) are not immunogenic, and only rare CDNs have been linked to tumor rejection. Thus, the rules of tumor antigen...
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