Article

Immunotherapeutic Potential of Mutated NPM1 for the Treatment of AML

2024-06-20

Abstract excerpt

Acute myeloid leukemia (AML) is a malignant disease of the blood and bone marrow that is characterized by uncontrolled clonal proliferation of abnormal myeloid progenitor cells. Nucleophosmin 1 (NPM1) gene mutations are the most common genetic abnormality in AML, detectable in blast cells from about one third of adults with AML. AML NPM1mut is recognized as a separate entity in the World Health Organization (WHO)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96e3ef63-7d86-59d5-9765-d98ad06fbe06
DOI: 10.20944/preprints202406.1388.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunotherapeutic Potential of Mutated NPM1 for the Treatment of AMLDOI 10.20944/preprints202406.1388.v1Read

Targeted therapy in NPM1-mutated AML: Knowns and unknownsSemantic proximity Read

Biological and clinical consequences of NPM1 mutations in AML.Semantic proximity Read

Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody.Semantic proximity Read

The interaction between common genetic mutations in AML and the immune landscape: mechanisms and implications for immune responseSemantic proximity Read

Recent advances in AML with mutated NPM1.Semantic proximity Read

Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)Semantic proximity Read

How I diagnose and treat NPM1 -mutated AMLSemantic proximity Read

Biology and Management of Acute Myeloid Leukemia With Mutated NPM1.Semantic proximity Read

Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia.Semantic proximity Read

NPM1-Mutated Acute Myeloid Leukemia: Recent Developments and Open Questions.Semantic proximity Read

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions.Semantic proximity Read

Current status and future perspectives in targeted therapy of NPM1-mutated AML.Semantic proximity Read