Article
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2022
Dong Han, Ham James Dongjoo, Hu Guangan, Xie Guozhu, Vergara Juliana, Liang Yong, Ali Alaa, Tarannum Mubin, Donner Hannah, Baginska Joanna, Abdulhamid Yasmin, Dinh Khanhlinh, Soiffer Robert J, Ritz Jerome, Glimcher Laurie H, Chen Jianzhu, Romee Rizwan
Abstract excerpt
Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 and IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CIML NK cells have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.