Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study.

doi:10.3389/fimmu.2025.1571508

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Article

Protective effects for HLA-B40:01 and C03:04 in NPM1-mutated AML: result of a large HLA association study.

Frontiers in immunology - 1 Jan 2025

Rücker-Braun Elke, Falk Bose, Baldauf Henning, Massalski Carolin, Schäfer Gesine, Altmann Heidi, Sauter Jürgen, Solloch Ute V, Lange Vinzenz, Egger-Heidrich Katharina, Kunadt Desiree, Stölzel Friedrich, Röllig Christoph, Middeke Jan M, von Bonin Malte, Thiede Christian, Schmidt Alexander H, Bornhäuser Martin, Schetelig Johannes, Heidenreich Falk

Abstract excerpt

Introduction: Mutations in the nucleophosmin 1 gene (NPM1) are common and recurrent molecular abnormalities in acute myeloid leukemia (AML). NPM1 mutations are considered to be positive prognostic factors. The beneficial effect may be due to immune responses mediated by cytotoxic T cells targeting HLA-presented peptides derived from mutated NPM1 and thereby suppressing mutated NPM1-positive hematopoiesis. While...

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Topics

Humans
Nucleophosmin
Leukemia, Myeloid, Acute
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Female

Nuclear Proteins

Middle Aged

Aged

Adult

Alleles

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40557158
DOI: 10.3389/fimmu.2025.1571508
PMCID: PMC12185502

Genes

NPM1
DNMT3A

Provenance

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