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Article

Absence of pre-transplant T cell response against LAA is associated with Flt3-ITD mutation and increased relapse-risk in AML patients with HSCT.

Immunotherapy - 1 Feb 2025

Šťastná-Marková Markéta, Hainz Petr, Kryštofová Jitka, Macková Jana, Roubalová Kateřina, Vydra Jan, Němečková Šárka

Abstract excerpt

AIMS: This study aimed to examine changes in the repertoire of functional T-cells specific for six leukemia-associated antigens (LAA), including WT1, PRAME, MUC1, CCNA1, NPM1, and NPM1c, during immune reconstitution following allogeneic transplantation of hematopoietic stem cells (HSCT) in patients with acute myeloid leukemia. PATIENTS & METHODS: LAA-specific T cell response was measured by ELISPOT- IFNγ and...

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Share to Antigens, Neoplasm
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Leukemia, Myeloid, Acute

Share to Nucleophosmin

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Share to T-Lymphocytes

Share to Transplantation, Homologous

Source

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Identifiers

PMID: 40099461
DOI: 10.1080/1750743X.2025.2478804
PMCID: PMC11951724

Genes

NPM1
CCNA1
MUC1
PRAME
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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