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Article

Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion.

PLoS genetics - 1 Sept 2021

Wu Pei-Shang, Grosser Jan, Cameron Donald P, Baranello Laura, Ström Lena

Abstract excerpt

The structural maintenance of chromosome (SMC) complex cohesin mediates sister chromatid cohesion established during replication, and damage-induced cohesion formed in response to DSBs post-replication. The translesion synthesis polymerase Polη is required for damage-induced cohesion through a hitherto unknown mechanism. Since Polη is functionally associated with transcription, and transcription triggers de novo...

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Identifiers

PMID: 34499654
DOI: 10.1371/journal.pgen.1009763
PMCID: PMC8454932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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