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Article

The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit.

Mitochondrion - 1 Jul 2020

Do Yura, Matsuda Shigeru, Inatomi Teppei, Nakada Kazuto, Yasukawa Takehiro, Kang Dongchon

Abstract excerpt

Human DNA polymerase γ (POLG) is a mitochondria-specific replicative DNA polymerase consisting of a single catalytic subunit, POLGα, and a dimeric accessory subunit, POLGβ. To gain a deeper understanding of the role of POLGβ, we knocked out this protein in cultured human cybrid cells and established numerous knockout clones. POLGβ-knockout clones presented a clear phenotype of mitochondrial DNA loss, indicating...

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Identifiers

PMID: 32470614
DOI: 10.1016/j.mito.2020.05.008

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