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Article

Unfolded protein response in hepatitis C virus infection

20 May 2014

Abstract excerpt

Hepatitis C virus (HCV) is a single-stranded, positive-sense RNA virus of clinical importance. The virus establishes a chronic infection and can progress from chronic hepatitis, steatosis to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The mechanisms of viral persistence and pathogenesis are poorly understood. Recently the unfolded protein response (UPR), a cellular homeostatic response to endoplasmic...

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PMID: 24904547
DOI: 10.3389/fmicb.2014.00233

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