Article
Using DNA sequencing data to quantify T cell fraction and therapy response.
Nature - 1 Sept 2021
Bentham Robert, Litchfield Kevin, Watkins Thomas B K, Lim Emilia L, Rosenthal Rachel, Martínez-Ruiz Carlos, Hiley Crispin T, Bakir Maise Al, Salgado Roberto, Moore David A, Jamal-Hanjani Mariam, Swanton Charles, McGranahan Nicholas
Abstract excerpt
The immune microenvironment influences tumour evolution and can be both prognostic and predict response to immunotherapy1,2. However, measurements of tumour infiltrating lymphocytes (TILs) are limited by a shortage of appropriate data. Whole-exome sequencing (WES) of DNA is frequently performed to calculate tumour mutational burden and identify actionable mutations. Here we develop T cell exome TREC tool (T...
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