Article

Whole-genome sequencing uncovers the genomic determinants of therapeutic resistance to immune checkpoint blockade

2023-09-26

Abstract excerpt

<title>Abstract</title> <p>Checkpoint inhibitors (CPI), ameliorate the anti-tumour response by blocking inhibitory immune checkpoint receptors, and have revolutionised the treatment of advanced cancers. However, the prediction of treatment response is suboptimal, and there remains a strong reliance on tumour mutation burden (TMB). Studies to date are limited to whole exome sequencing (WES), with no data yet repor...

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Literature Corpus work: 43e412b5-3b5f-5714-851a-75a1052b3127
DOI: 10.21203/rs.3.rs-3318337/v1

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