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Article

Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells.

Biomaterials - 1 May 2013

Yuan Minting, Yeung Chiu Wai, Li Yuk Yin, Diao Huajia, Cheung K M C, Chan D, Cheah K, Chan Pui Barbara

Abstract excerpt

Recent attempts to treat disc degeneration with mesenchymal stem cells (MSCs) showed encouraging results. Differentiating MSCs towards nucleus pulposus cell (NPC)-like lineages represents a speculative mechanism. Niche factors including hypoxia, growth factors and cell-cell interactions have been suggested but the matrix niche factor has not been studied. Our collagen microencapsulation provides a 3D model to...

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PMID: 23465833
DOI: 10.1016/j.biomaterials.2013.02.004

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MSC

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