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Article

Integrin-mediated interactions with a laminin-presenting substrate modulate biosynthesis and phenotypic expression for cells of the human nucleus pulposus.

European cells & materials - 24 Jun 2021

Speer J, Barcellona M, Jing L, Liu B, Lu M, Kelly M, Buchowski J, Zebala L, Luhmann S, Gupta M, Setton L

Abstract excerpt

With aging and pathology, cells of the nucleus pulposus (NP) de-differentiate towards a fibroblast-like phenotype, a change that contributes to degeneration of the intervertebral disc (IVD). Laminin isoforms are a component of the NP extracellular matrix during development but largely disappear in the adult NP tissue. Exposing human adult NP cells to hydrogels made from PEGylated-laminin-111 (PEGLM) has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34160056
DOI: 10.22203/eCM.v041a50
PMCID: PMC8378851

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