Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyaluronan composite bioink preserves nucleus pulposus cell phenotype in a stiffness-dependent manner.

Carbohydrate polymers - 1 Apr 2025

Miklosic Gregor, De Oliveira Stéphanie, Schlittler Maja, Le Visage Catherine, Hélary Christophe, Ferguson Stephen J, D'Este Matteo

Abstract excerpt

Intervertebral disc degeneration is a major cause of neck and back pain, representing a significant global socioeconomic burden. The polysaccharide hyaluronan is key to maintaining disc physiology and mediating disc disease through its structural and biological roles in the nucleus pulposus, a component of the intervertebral disc highly susceptible to degeneration. In this study, we introduce a novel composite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocompatible Materials
Share to Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Collagen

Share to Hyaluronic Acid

Share to Intervertebral Disc

Share to Intervertebral Disc Degeneration

Share to Tissue Engineering

Source

Identifiers

PMID: 39914983
DOI: 10.1016/j.carbpol.2025.123277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyaluronan composite bioink preserves nucleus pulposus cell phenotype in a stiffness-dependent manner.PMID 39914983Read ↗

A novel thiol-modified hyaluronan and elastin-like polypetide composite material for tissue engineering of the nucleus pulposus of the intervertebral disc.Semantic proximity Read ↗

Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration.Semantic proximity Read ↗

Fibronectin Peptide Modified Hydrogels Activate a Contractile Phenotype in Nucleus Pulposus Cells.Semantic proximity Read ↗

Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies.Semantic proximity Read ↗

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and RegenerationSemantic proximity Read ↗

Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 InteractionSemantic proximity Read ↗

Engineered Peptide-Functionalized Hydrogels Modulate the RNA Transcriptome of Human Nucleus Pulposus Cells In VitroSemantic proximity Read ↗

Integrin and syndecan binding peptide-conjugated alginate hydrogel for modulation of nucleus pulposus cell phenotype.Semantic proximity Read ↗

NTG-102: A Refined Molecular Therapeutic to Treat Degenerative Disc DiseaseSemantic proximity Read ↗

WITHDRAWN: Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical BioprintingSemantic proximity Read ↗

The regeneration of degenerated intervertebral discs via tissue engineering, biomaterials, and gene or cell-based therapiesSemantic proximity Read ↗

Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.