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Article

Fibronectin Peptide Modified Hydrogels Activate a Contractile Phenotype in Nucleus Pulposus Cells.

Advanced biology - 1 Nov 2025

Naha Ananya, Sorensen John, Lazarte Santiago, Joshi Sailesti, Driscoll Tristan P

Abstract excerpt

Degenerative disc disease is strongly associated with low back pain, making it a leading cause of disability. With injury and age, cellular remodeling of the disc tissue leads to compositional changes, stiffening, and loss of stress relaxation, particularly in the central gelatinous nucleus pulposus (NP) region of the disc. As part of this extracellular matrix (ECM) remodeling, there is an increase in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40716078
DOI: 10.1002/adbi.202500315
PMCID: PMC12323826

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