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Article

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.

Nature communications - 6 Sept 2021

Sun Jiangming, Wang Yunpeng, Folkersen Lasse, Borné Yan, Amlien Inge, Buil Alfonso, Orho-Melander Marju, Børglum Anders D, Hougaard David M, Melander Olle, Engström Gunnar, Werge Thomas, Lage Kasper

Abstract excerpt

A promise of genomics in precision medicine is to provide individualized genetic risk predictions. Polygenic risk scores (PRS), computed by aggregating effects from many genomic variants, have been developed as a useful tool in complex disease research. However, the application of PRS as a tool for predicting an individual's disease susceptibility in a clinical setting is challenging because PRS typically provide...

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Identifiers

PMID: 34489429
DOI: 10.1038/s41467-021-25014-7
PMCID: PMC8421428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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