Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.

Antimicrobial agents and chemotherapy - 1 Nov 2008

Memmi Guido, Filipe Sergio R, Pinho Mariana G, Fu Zhibiao, Cheung Ambrose

Abstract excerpt

Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (MRSA) (CA-MRSA) strains in healthy individuals have raised concerns worldwide. CA-MRSA strains differ from hospital-acquired MRSAs by virtue of their genomic background and increased virulence in animal models. Here, we show that in two common CA-MRSA isolates, USA300 and MW2 (USA400), a loss of penicillin binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Lactam Resistance
Share to Cefoxitin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Community-Acquired Infections

Share to Methicillin Resistance

Share to Methicillin-Resistant Staphylococcus aureus

Share to Penicillin-Binding Proteins

Share to Penicillins

Share to Staphylococcal Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 18725435
DOI: 10.1128/AAC.00049-08
PMCID: PMC2573147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.PMID 18725435Read ↗

An Update on the Role of Penicillin Binding Protein-4 (PBP4) in β-Lactam Resistance of <em>Staphylococcus aureus</em>Semantic proximity Read ↗

A Nonclassical Mechanism of β-Lactam Resistance in Methicillin-Resistant Staphylococcus aureus and Its Effect on VirulenceSemantic proximity Read ↗

PBP4: A New Perspective on Staphylococcus aureus β-Lactam ResistanceSemantic proximity Read ↗

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus.Semantic proximity Read ↗

A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes.Semantic proximity Read ↗

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec geneSemantic proximity Read ↗

PBP4-mediated β-lactam resistance among clinical strains of Staphylococcus aureusSemantic proximity Read ↗

Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance in Staphylococcus aureusSemantic proximity Read ↗

Methicillin-resistant Staphylococcus aureus has phenotypic variation in mecA expression that alters antibiotic sensitivity.Semantic proximity Read ↗

Structural and Regulatory Changes in PBP4 Trigger Decreased β-Lactam Susceptibility in Enterococcus faecalisSemantic proximity Read ↗

Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance.Semantic proximity Read ↗

β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.