Article
Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains.
Antimicrobial agents and chemotherapy - 1 Nov 2008
Memmi Guido, Filipe Sergio R, Pinho Mariana G, Fu Zhibiao, Cheung Ambrose
Abstract excerpt
Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (MRSA) (CA-MRSA) strains in healthy individuals have raised concerns worldwide. CA-MRSA strains differ from hospital-acquired MRSAs by virtue of their genomic background and increased virulence in animal models. Here, we show that in two common CA-MRSA isolates, USA300 and MW2 (USA400), a loss of penicillin binding...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Base Sequence
- Cefoxitin
- Community-Acquired Infections
- DNA Primers
- DNA, Bacterial
- Drug Therapy, Combination
- Gene Deletion
- Genes, Bacterial