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Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas

1 Jan 2021

Abstract excerpt

Abstract Background Diffuse intrinsic pontine gliomas (DIPG), within diffuse midline gliomas are aggressive pediatric brain tumors characterized by histone H3-K27M mutation. Small-molecule inhibitors for the EZH2-H3K27 histone methyltransferase have shown promise in preclinical animal models of DIPG, despite having little effect on DIPG cells in vitro. Therefore, we hypothesized that the effect of EZH2 inhibition...

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Share to Epigenetics and DNA Methylation
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PMID: 34485907
DOI: 10.1093/noajnl/vdab096

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