Article
A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 1999
Leder A, Wiener E, Lee M J, Wickramasinghe S N, Leder P
Abstract excerpt
Thalassemia is a heritable human anemia caused by a variety of mutations that affect expression of the alpha- or the beta-chain of hemoglobin. The expressivity of the phenotype is likely to be influenced by unlinked modifying genes. Indeed, by using a mouse model of alpha-thalassemia, we find that its phenotype is strongly influenced by the genetic background in which the alpha-thalassemia mutation resides...
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