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Translesion activity of PrimPol on DNA with cisplatin and DNA–protein cross-links

2 Sept 2021

Abstract excerpt

Abstract Human PrimPol belongs to the archaeo-eukaryotic primase superfamily of primases and is involved in de novo DNA synthesis downstream of blocking DNA lesions and non-B DNA structures. PrimPol possesses both DNA/RNA primase and DNA polymerase activities, and also bypasses a number of DNA lesions in vitro. In this work, we have analyzed translesion synthesis activity of PrimPol in vitro on DNA with an...

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PMID: 34475447
DOI: 10.1038/s41598-021-96692-y

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