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Article

Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

Zhao Ye, Biertümpfel Christian, Gregory Mark T, Hua Yue-Jin, Hanaoka Fumio, Yang Wei

Abstract excerpt

Cisplatin (cis-diamminedichloroplatinum) and related compounds cause DNA damage and are widely used as anticancer agents. Chemoresistance to cisplatin treatment is due in part to translesion synthesis by human DNA polymerase η (hPol η). Here, we report crystal structures of hPol η complexed with intrastrand cisplatin-1,2-cross-linked DNA, representing four consecutive steps in translesion synthesis. In contrast...

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Identifiers

PMID: 22529383
DOI: 10.1073/pnas.1202681109
PMCID: PMC3358888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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