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Article

Transcriptional control of brain tumor stem cells by a carbohydrate binding protein.

Cell reports - 31 Aug 2021

Sharanek Ahmad, Burban Audrey, Hernandez-Corchado Aldo, Madrigal Ariel, Fatakdawala Idris, Najafabadi Hamed S, Soleimani Vahab D, Jahani-Asl Arezu

Abstract excerpt

Brain tumor stem cells (BTSCs) and intratumoral heterogeneity represent major challenges in glioblastoma therapy. Here, we report that the LGALS1 gene, encoding the carbohydrate binding protein, galectin1, is a key regulator of BTSCs and glioblastoma resistance to therapy. Genetic deletion of LGALS1 alters BTSC gene expression profiles and results in downregulation of gene sets associated with the mesenchymal...

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Identifiers

PMID: 34469737
DOI: 10.1016/j.celrep.2021.109647

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