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Article

Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

10 Jun 2021

Abstract excerpt

Abstract Recently, we involved the carbohydrate-binding protein Galectin-3 (Gal-3) as a druggable target for KRAS-mutant-addicted lung and pancreatic cancers. Here, using glioblastoma patient-derived stem cells (GSCs), we identify and characterize a subset of Gal-3high glioblastoma (GBM) tumors mainly within the mesenchymal subtype that are addicted to Gal-3-mediated macropinocytosis. Using both genetic and...

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PMID: 34112916
DOI: 10.1038/s42003-021-02258-z

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