Article
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 2 May 2006
Sakaguchi Masanori, Shingo Tetsuro, Shimazaki Takuya, Okano Hirotaka James, Shiwa Mieko, Ishibashi Satoru, Oguro Hideyuki, Ninomiya Mikiko, Kadoya Toshihiko, Horie Hidenori, Shibuya Akira, Mizusawa Hidehiro, Poirier Françoise, Nakauchi Hiromitsu, Sawamoto Kazunobu, Okano Hideyuki
Abstract excerpt
In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed...
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