The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability

Abstract excerpt

<h4>SUMMARY</h4> Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their functional role in gliomagenesis and their potential as treatment targets. To identify therapeutically targetable opportunities among aGPCR family members in unbiased fashion, we analyzed expression levels of all aGPCRs in GBM and non-neopl...

Topics

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• Antigens, CD
• Cancer, Stress, Anesthesia, and Immune Response
• Chemokine receptors and signaling
• Monoclonal and Polyclonal Antibodies Research
• Neoplasm Invasiveness
• Neuroscience and Neuropharmacology Research
• Receptor Mechanisms and Signaling
• Receptors, G-Protein-Coupled

Identifiers and source

Literature Corpus work

831eca31-8f22-592b-9a58-9336e34dd68c

DOI

10.1101/2023.08.31.555733