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Article

Histone-mutant glioma presenting as diffuse leptomeningeal disease.

CNS oncology - 1 Sept 2021

Nadkarni Tanvi, Hamilton Kimberly, Niazi Faraze, Ward Melanie, Okakpu Uchenna, Castellani Rudolph J, Prisneac Ion, Sener Ugur

Abstract excerpt

Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M mutations typically associated with a posterior fossa midline tumor location and poor prognosis. Leptomeningeal disease is a known complication of histone-mutant glioma, but uncommon at the time of initial diagnosis. We describe a case of...

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Identifiers

PMID: 34469205
DOI: 10.2217/cns-2021-0008
PMCID: PMC8461753

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