The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

doi:10.1038/s41467-021-25664-7

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Article

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.

Nature communications - 13 Sept 2021

Khateb Ali, Deshpande Anagha, Feng Yongmei, Finlay Darren, Lee Joo Sang, Lazar Ikrame, Fabre Bertrand, Li Yan, Fujita Yu, Zhang Tongwu, Yin Jun, Pass Ian, Livneh Ido, Jeremias Irmela, Burian Carol, Mason James R, Almog Ronit, Horesh Nurit, Ofran Yishai, Brown Kevin, Vuori Kristiina, Jackson Michael, Ruppin Eytan, Deshpande Aniruddha J, Ronai Ze'ev A

Abstract excerpt

Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the ubiquitin ligase RNF5 contributes to AML development and survival. High RNF5 expression in AML patient specimens correlates with poor prognosis. RNF5 inhibition decreases AML cell growth in culture, in patient-derived xenograft (PDX) samples and in vivo, and...

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Identifiers

PMID: 34518534
DOI: 10.1038/s41467-021-25664-7
PMCID: PMC8437979

Genes

RNF5
RBBP4

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