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Article

Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation

6 Feb 2007

Abstract excerpt

RBM15 is the fusion partner with MKL in the t(1;22) translocation of acute megakaryoblastic leukemia. To understand the role of the RBM15-MKL1 fusion protein in leukemia, we must understand the normal functions of RBM15 and MKL. Here, we show a role for Rbm15 in myelopoiesis. Rbm15 is expressed at highest levels in hematopoietic stem cells and at more moderate levels during myelopoiesis of murine cell lines and...

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PMID: 17283045
DOI: 10.1128/mcb.01339-06

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