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NRF2 activation induced by PML‐RARα promotes microRNA 125b‐1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia

1 May 2021

Abstract excerpt

Dear Editor, Chromosomal translocation is a hallmark of acute myeloid leukemia (AML), often leading to gene rearrangements and expression of a fusion oncoprotein.1 In this work, we described the fusion oncoprotein promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) as a new mechanism for nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) activation during leukemogenesis and suggest that...

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PMID: 34047481
DOI: 10.1002/ctm2.418

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