Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk.

JCI insight - 8 Oct 2021

Mkorombindo Takudzwa, Tran-Nguyen Thi K, Yuan Kaiyu, Zhang Yingze, Xue Jianmin, Criner Gerard J, Kim Young-Il, Pilewski Joseph M, Gaggar Amit, Cho Michael H, Sciurba Frank C, Duncan Steven R

Abstract excerpt

A role for hereditary influences in the susceptibility for chronic obstructive pulmonary disease (COPD) is widely recognized. Cytotoxic lymphocytes are implicated in COPD pathogenesis, and functions of these leukocytes are modulated by interactions between their killer cell Ig-like receptors (KIR) and human leukocyte antigen-Class I (HLA-Class I) molecules on target cells. We hypothesized HLA-Class I and KIR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HLA-C Antigens

Share to Polymorphism, Genetic

Share to Pulmonary Disease, Chronic Obstructive

Share to Receptors, KIR

Source

Open in PubMed Open full text

Identifiers

PMID: 34464355
DOI: 10.1172/jci.insight.150187
PMCID: PMC8525585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk.PMID 34464355Read ↗

KIR-HLA gene diversities and susceptibility to lung cancer.Semantic proximity Read ↗

HLA-C and killer cell immunoglobulin-like receptor genes in idiopathic bronchiectasis.Semantic proximity Read ↗

Lack of association between KIR and HLA-C type and susceptibility to idiopathic bronchiectasis.Semantic proximity Read ↗

Killer cell immunoglobulin-like receptor genotypes and haplotypes with susceptibility to pulmonary tuberculosis infection.Semantic proximity Read ↗

KIR2DL2/S2 and HLA-C C1C1 genotype is associated with better response to treatment and prolonged survival of patients with non-small cell lung cancer in a Polish Caucasian population.Semantic proximity Read ↗

Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer.Semantic proximity Read ↗

A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population.Semantic proximity Read ↗

HLA-DRB1 Alleles are Associated With COPD in a Latin American Admixed Population.Semantic proximity Read ↗

The killer immunoglobulin-like receptor (KIR) group A haplotype is associated with bronchiolitis obliterans syndrome after lung transplantation.Semantic proximity Read ↗

Potential implication of activating killer cell immunoglobulin-like receptor and HLA in onset of pulmonary tuberculosis.Semantic proximity Read ↗

Germline HLA heterozygosity is associated with decreased lung cancer risk.Semantic proximity Read ↗

HLA distribution in COPD patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.