Article
A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population.
Respirology (Carlton, Vic.) - 1 Jan 2012
Kinose Daisuke, Ogawa Emiko, Hirota Tomomitsu, Ito Isao, Kudo Megumi, Haruna Akane, Marumo Satoshi, Hoshino Yuma, Muro Shigeo, Hirai Toyohiro, Sakai Hiroaki, Date Hiroshi, Tamari Mayumi, Mishima Michiaki
Abstract excerpt
BACKGROUND AND OBJECTIVE: Genetic background is thought to be one of the risk factors for development of COPD. Recently, it has been proposed that the innate immune system is involved in the pathophysiology of COPD. We hypothesized that polymorphisms in the nucleotide-binding and oligomerization domain (NOD)1 and NOD2 genes would be associated with the pathogenesis of COPD. In addition, the associations between...
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