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Article

Whole exome sequencing of 80 cases of sporadic mitral valve prolapse reveals novel disease-associated genes and variants in a Southern Chinese population.

Genes & genomics - 1 Jun 2025

Wang Qiuji, Zhao Junfei, Huang Huanlei

Abstract excerpt

BACKGROUND: Mitral valve prolapse (MVP) is a common valvular disorder with a complex genetic basis. While familial MVP-related genes have been identified, the genetic determinants of sporadic MVP remain unclear. OBJECTIVE: This study aims to identify causative genes associated with sporadic MVP and analyze genotype-phenotype correlations in a southern Chinese population. METHODS: Whole-exome sequencing (WES) was...

Read the complete abstract on PubMed

Topics

Adult
Aged
Female
Humans
Male
Middle Aged
China

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Connectin

Exome Sequencing

Filamins

Genetic Association Studies

Genetic Predisposition to Disease

Mitral Valve Prolapse

Mutation

East Asian People

Source

Identifiers

PMID: 40131712
DOI: 10.1007/s13258-025-01626-x

Genes

MVP
COL11A1
COL1A2
FLNA
FLNC
PRDM5
TGFB1
TTN
ZNF469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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