Article
Somatic PTPN11 mutations in childhood acute myeloid leukaemia.
British journal of haematology - 1 May 2005
Tartaglia Marco, Martinelli Simone, Iavarone Ivano, Cazzaniga Giovanni, Spinelli Monica, Giarin Emanuela, Petrangeli Valentina, Carta Claudio, Masetti Riccardo, Aricò Maurizio, Locatelli Franco, Basso Giuseppe, Sorcini Mariella, Pession Andrea, Biondi Andrea
Abstract excerpt
Somatic mutations in PTPN11, the gene encoding the transducer SHP-2, have emerged as a novel class of lesions that upregulate RAS signalling and contribute to leukaemogenesis. In a recent study of 69 children and adolescents with de novo acute myeloid leukaemia (AML), we documented a non-random distribution of PTPN11 mutations among French-American-British (FAB) subtypes. Lesions were restricted to FAB-M5 cases,...
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