Article

Resolving single-cell heterogeneity from hundreds of thousands of cells through sequential hybrid clustering and NMF

2019-04-14

Abstract excerpt

<h4>ABSTRACT</h4> The rapid proliferation of single-cell RNA-Sequencing (scRNA-Seq) technologies has spurred the development of diverse computational approaches to detect transcriptionally coherent populations. While the complexity of the algorithms for detecting heterogeneity have increased, most existing algorithms require significant user-tuning, are heavily reliant on dimensionality reduction techniques and a...

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Literature Corpus work: 799c2fc8-3a4d-5c93-a7c0-587ef954139b
DOI: 10.1101/608869

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