Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.

The Journal of experimental medicine - 22 Jan 2007

Lahl Katharina, Loddenkemper Christoph, Drouin Cathy, Freyer Jennifer, Arnason Jon, Eberl Gérard, Hamann Alf, Wagner Hermann, Huehn Jochen, Sparwasser Tim

Abstract excerpt

The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Chromosomes, Artificial, Bacterial
Share to Diphtheria Toxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

Share to Heparin-binding EGF-like Growth Factor

Share to Intercellular Signaling Peptides and Proteins

Share to Lymphoproliferative Disorders

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 17200412
DOI: 10.1084/jem.20061852
PMCID: PMC2118432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17200412-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.PMID 17200412Read ↗

Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice.Semantic proximity Read ↗

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulationSemantic proximity Read ↗

FOXP3 acts as a rheostat of the immune response.Semantic proximity Read ↗

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.Semantic proximity Read ↗

Control of regulatory T cell development by the transcription factor Foxp3.Semantic proximity Read ↗

IPEX and FOXP3: clinical and research perspectives.Semantic proximity Read ↗

FOXP3: of mice and men.Semantic proximity Read ↗

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.Semantic proximity Read ↗

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Semantic proximity Read ↗

Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted MiceSemantic proximity Read ↗

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis.Semantic proximity Read ↗

Foxp3 in the Immune SystemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.