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SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice

26 Aug 2021

Abstract excerpt

Significance Calcineurin is a target of immunosuppressive drugs such as cyclosporine A and tacrolimus. In the immune system, calcineurin interacts with NFAT via the PxIxIT motif to activate T cells. In contrast, little is known about the proteins that interact with a testis-enriched calcineurin that is essential for sperm motility and male fertility. Here, we discovered that calcineurin interacts with SPATA33 via...

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PMID: 34446558
DOI: 10.1073/pnas.2106673118

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