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Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm–egg binding

20 Jul 2018

Abstract excerpt

Testis-specific PRSS55 is a highly conserved chymotrypsin-like serine protease among mammalian species. So far, the physiological function of PRSS55 remains unknown. Here, we show that PRSS55 is a GPI-anchored membrane protein, specifically expressed in adult mouse testis and mainly observed in the luminal side of seminiferous tubules and sperm acrosome. Mice deficient for Prss55 develop male infertile with...

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PMID: 30032357
DOI: 10.1007/s00018-018-2878-9

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