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Article

Deletion of the Spata3 Gene Induces Sperm Alterations and In Vitro Hypofertility in Mice.

International journal of molecular sciences - 16 Feb 2021

Girault Marie-Sophie, Dupuis Sophie, Ialy-Radio Côme, Stouvenel Laurence, Viollet Cécile, Pierre Rémi, Favier Maryline, Ziyyat Ahmed, Barbaux Sandrine

Abstract excerpt

Thanks to the analysis of an Interspecific Recombinant Congenic Strain (IRCS), we previously defined the Mafq1 quantitative trait locus as an interval on mouse Chromosome 1 associated with male hypofertility and ultrastructural abnormalities. We identified the Spermatogenesis associated protein 3 gene (Spata3 or Tsarg1) as a pertinent candidate within the Mafq1 locus and performed the CRISPR-Cas9 mediated...

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Source

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Identifiers

PMID: 33669425
DOI: 10.3390/ijms22041959
PMCID: PMC7920483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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