Article
Small Structural Proteins E and M Render the SARS-CoV-2 Pseudovirus More Infectious and Reveal the Phenotype of Natural Viral Variants.
International journal of molecular sciences - 23 Aug 2021
Wang Hsin-I, Chuang Zih-Shiuan, Kao Yu-Ting, Lin Yi-Ling, Liang Jian-Jong, Liao Chun-Che, Liao Ching-Len, Lai Michael M C, Yu Chia-Yi
Abstract excerpt
The SARS-CoV-2 pseudovirus is a commonly used strategy that mimics certain biological functions of the authentic virus by relying on biological legitimacy at the molecular level. Despite the fact that spike (S), envelope (E), and membrane (M) proteins together wrap up the SARS-CoV-2 virion, most of the reported pseudotype viruses consist of only the S protein. Here, we report that the presence of E and M...
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