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Article

Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2005

Yang Zhi-yong, Werner Heidi C, Kong Wing-pui, Leung Kwanyee, Traggiai Elisabetta, Lanzavecchia Antonio, Nabel Gary J

Abstract excerpt

Molecular characterization of the severe acute respiratory syndrome coronavirus has revealed genetic diversity among isolates. The spike (S) glycoprotein, the major target for vaccine and immune therapy, shows up to 17 substitutions in its 1,255-aa sequence; however, the biologic significance of these changes is unknown. Here, the functional effects of S mutations have been determined by analyzing their affinity...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carboxypeptidases

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Share to Severe acute respiratory syndrome-related coronavirus

Share to Spike Glycoprotein, Coronavirus

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Source

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Identifiers

PMID: 15642942
DOI: 10.1073/pnas.0409065102
PMCID: PMC545557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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