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Article

Key mutations in the spike protein of SARS-CoV-2 affecting neutralization resistance and viral internalization.

Journal of medical virology - 1 Jan 2023

Wang Qiong, Ye Sheng-Bao, Zhou Zhi-Jian, Song A-Ling, Zhu Xi, Peng Jia-Mei, Liang Rui-Min, Yang Chen-Hui, Yu Xiao-Wei, Huang Xun, Yu Jie, Qiu Ye, Ge Xing-Yi

Abstract excerpt

To control the ongoing COVID-19 pandemic, a variety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have been developed. However, the rapid mutations of SARS-CoV-2 spike (S) protein may reduce the protective efficacy of the existing vaccines which is mainly determined by the level of neutralizing antibodies targeting S. In this study, we screened prevalent S mutations and constructed 124...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36519597
DOI: 10.1002/jmv.28407
PMCID: PMC9877909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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