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Article

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.

International journal of molecular sciences - 18 Aug 2021

Schulze-Krebs Anja, Canneva Fabio, Stemick Judith, Plank Anne-Christine, Harrer Julia, Bates Gillian P, Aeschlimann Daniel, Steffan Joan S, von Hörsten Stephan

Abstract excerpt

Mammalian transglutaminases (TGs) catalyze calcium-dependent irreversible posttranslational modifications of proteins and their enzymatic activities contribute to the pathogenesis of several human neurodegenerative diseases. Although different transglutaminases are found in many different tissues, the TG6 isoform is mostly expressed in the CNS. The present study was embarked on/undertaken to investigate...

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Source

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Identifiers

PMID: 34445621
DOI: 10.3390/ijms22168914
PMCID: PMC8396294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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