Article
Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.
The Journal of biological chemistry - 15 Jul 2011
Zucchelli Silvia, Marcuzzi Federica, Codrich Marta, Agostoni Elena, Vilotti Sandra, Biagioli Marta, Pinto Milena, Carnemolla Alisia, Santoro Claudio, Gustincich Stefano, Persichetti Francesca
Abstract excerpt
Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin (HTT), which confers aggregation-promoting properties to amino-terminal fragments of the protein (N-HTT). Mutant N-HTT aggregates are enriched for ubiquitin and contain ubiquitin E3 ligases, thus suggesting a role for ubiquitination in aggregate formation. Here, we report that tumor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.