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Article

Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.

The Journal of biological chemistry - 22 Jun 2012

Culver Brady P, Savas Jeffrey N, Park Sung K, Choi Jeong H, Zheng Shuqiu, Zeitlin Scott O, Yates John R, Tanese Naoko

Abstract excerpt

Huntington disease is a neurodegenerative disorder caused by a CAG repeat amplification in the gene huntingtin (HTT) that is reflected by a polyglutamine expansion in the Htt protein. Nearly 20 years of research have uncovered roles for Htt in a wide range of cellular processes, and many of these...

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Source

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Identifiers

PMID: 22556411
DOI: 10.1074/jbc.M112.359307
PMCID: PMC3381125

Genes

HTT
RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22556411-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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