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Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas.

Cells - 8 Aug 2021

Vázquez Cervantes Gustavo Ignacio, Pineda Benjamín, Ramírez Ortega Daniela, Salazar Alelí, González Esquivel Dinora Fabiola, Rembao Daniel, Zavala Vega Sergio, Gómez-Manzo Saúl, Pérez de la Cruz Gonzalo, Pérez de la Cruz Verónica

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. The enzyme indoleamine-2,3-dioxygenase (IDO), which participates in the rate-limiting step of tryptophan catabolism through the kynurenine pathway (KP), is associated with poor prognosis in patients with GBM. The metabolites produced after tryptophan oxidation have immunomodulatory properties that can support the immunosuppressor...

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Identifiers

PMID: 34440798
DOI: 10.3390/cells10082028
PMCID: PMC8393384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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